Novel Targets

Novel Targets

noveltargets.com
Bringing to life the science around innovative ne…
23: Modulating the Signal
Jul 5 • 36 min
In this episode we take a look a look at how cytokines can be employed to modulate the tumour microenvironment in favourable ways. You’ll hear various perspectives from numerous academic and industry experts who are active in research in this field,…
22: Practice, Pitfalls, and Possibilities
May 10 • 38 min
Welcome back to Season 4! In this latest episode, we take a look at data from immunotherapy clinical trials from several different angles and investigate the challenges associated presented by different combination partners, control arms, patient…
21: Playing With Fire
Jan 5 • 44 min
In this episode we’re exploring some controversial issues in cancer research including real world versus clinical trial experience and immune related toxicities, as well as highlighting strength and weaknesses around some encouraging new data with several…
20: Cancer Vaccine Renaissance
Oct 25, 2017 • 43 min
In this latest episode we’re exploring an up and coming area of cancer research, namely therapeutic cancer vaccines. If we want to jumpstart the immune system in cold/non-inflamed/desert tumours, then we need to find ways to attract more T cells into the…
19: Revolutionary Thinking Required
Sep 1, 2017 • 34 min
In this episode we’re exploring ways to jumpstart the immune system so that subsequent therapies can be more effective, especially in cold non-inflamed tumours. It is becoming increasingly clear that people with pre-existing immunity respond better to…
18: Shaping The Future
Jul 4, 2017 • 47 min
In the latest episode of Novel Targets, we take a look at new developments in breast cancer. Breast cancer can be organised into several distinct subsets for the purposes of treatment: - Hormone sensitive disease (HR+) - HER2+ - Triple negative breast…
17: Overcoming Immunotherapy Resistance
May 5, 2017 • 35 min
Welcome back to Season 3. In this episode we’re tackling one of the hottest topics in cancer research, why do cancer immunotherapies work in some people, but not in others? Why do they stop working? If we want to obtain long durable responses, then we…
16: Controversies In Hematology
Jan 6, 2017 • 46 min
This episode was recorded at the 2016 annual meeting of the American Society of Hematology (ASH) in San Diego. You’ll hear excerpts from interviews with leading experts, who discuss some of the latest clinical data and controversies in liquid cancers and…
15: Targeting Ovarian Cancer
Nov 2, 2016 • 29 min
In this episode, listeners receive a ticket to ride the Copenhagen Metro to the 2016 Congress of ESMO, the European Society for Medical Oncology. Along the way we hear from experts about targeting ovarian cancer and some of the latest data on PARP…
13: Immunotherapy or Bust
Jun 23, 2016 • 35 min
This episode discusses some of the cancer immunotherapy data presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. It’s the largest cancer meeting in the world, with over 35,000 attendees. You’ll hear Dr…
12: Of Mice and Men
May 20, 2016 • 38 min
In this episode you’ll hear from Dr Bernie Fox (pictured), Dr Ina Rhee and Emeritus Professor Kees Melief. We talked to all three scientists at the 2016 annual meeting of the American Association for Cancer Research (AACR) in New Orleans. One of the…
11: Cancer Immunity Cycle
Apr 29, 2016 • 34 min
Season 2 of Novel Targets kicks off with an episode on the Cancer Immunity Cycle. Back in 2013, Genentech scientists Drs Daniel Chen and Ira Mellman (pictured) published a paper in the journal Immunity: “Oncology meets Immunology: the cancer-immunity…
10: New Horizons in Hematology
Jan 7, 2016 • 32 min
Episode 10 is on New Horizons in Hematology and features excerpts from interviews recorded at last December’s annual meeting of the American Society of Hematology (ASH). In Orlando, we spoke to experts about some of the latest data in AML, Multiple…
9: Targeting the Microbiome
Dec 2, 2015 • 23 min
In this episode we’re looking at how to make therapies that target our immune system more effective. Could it be as simple as changing the composition of the bacteria in the gut, the intestinal microbiome that contains a gazillion bugs? Dr Tom Gajewski…
8: The Pioneers - Part 1
Nov 25, 2015 • 24 min
A pioneer is someone who helps develop something new and prepares the way for others to follow. We want to harness our immune system to fight and cure cancer. In this episode you’ll hear from two (of the many) pioneers in the field of cancer…
7: European Cancer Congress
Oct 27, 2015 • 38 min
More than 19,000 people from over 100 countries travelled to Vienna at the end of September 2015 for the European Cancer Congress. Cancer immunotherapy was the hot topic of the meeting. There were several late-breaking abstracts for clinical trials with…
6: Stepping On The Gas
Sep 22, 2015 • 29 min
Checkpoint inhibitors act to “release the break” cancer puts on the immune system. There are also immune agonists that are stimulatory in effect. They help to “step on the gas” and make the immune system more effective. In this episode you’ll hear Dr…
5: Titans Of Adoptive Cell Therapy
Aug 18, 2015 • 33 min
There are multiple ways to use the body’s immune system to fight cancer. One novel approach is through Adoptive Cell Therapy - you take T lymphocytes or “T cells” out of a patient - these are the warriors of the immune system - manipulate them in some way…
4: Non-Inflamed Tumor Show
Jul 21, 2015 • 34 min
Checkpoint inhibitors do not work well in cancers where there is no underlying immune response. One example of such a non-inflamed tumor is prostate cancer. So a key question is how do we convert a non-inflamed tumor (few T Cells present) into an inflamed…
3: ASCO Lung Cancer Show
Jun 12, 2015 • 39 min
Lung cancer is the No 1 cause of cancer related death in the United States. Which is why the whole of this episode is devoted to the latest lung cancer data presented at the 2015 annual meeting of the American Society of Clinical Oncology (ASCO) that took…
2: The Immune Biomarker Show
May 26, 2015 • 25 min
Biomarkers may help us predict who will respond to checkpoint inhibitors that target the PD1 PDL1 signaling pathway. They may also help us increase the number of patients that respond by understanding how to overcome suppression in the tumor…
1: The Checkpoints Show
Apr 30, 2015 • 26 min
The promise of cancer immunotherapy and in particular checkpoint inhibitors that target the PD1 PDL1 signaling pathway is the topic of this episode. We hear about the latest data presented at the annual meeting of the American Association for Cancer…
Prologue 3: Lung Cancer Immunotherapy
Apr 8, 2015 • 11 min
Roy Herbst MD PhD is Ensign Professor of Medicine (Medical Oncology) at Yale Cancer Center. Last November, at the 2014 annual meeting of the Society for Immunotherapy of Cancer (SITC) he gave an outstanding presentation on “Personalized Immunotherapy for…
Prologue 2: Using our Immune System to Fight Cancer
Mar 28, 2015 • 6 min
The first episode of the Novel Targets podcast will be produced after the annual meeting of the American Association of Cancer Research (AACR) in Philadelphia from April 18 - 22, 2015. In the meantime, we are putting up three prologues that set scene…
Prologue 1: Promise of CAR T Cell Cancer Immunotherapy
Mar 28, 2015 • 7 min
One of the hottest topics in Cancer Research is Cancer Immunotherapy: using the body’s immune system to fight cancer. To set the scene prior to the first podcast episode, we are sharing a report by Pieter Droppert that discusses the promise of Chimeric…