This Week in Virology

This Week in Virology
A netcast about viruses - the kind that make you sick
544: Immunogaga
Apr 21 • 107 min
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA.
543: Stoned and senile
Apr 14 • 108 min
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice.
542: Inside Microbiotix
Apr 7 • 65 min
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.
541: Cloaking devices
Mar 31 • 88 min
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again.
540: Wascally wiruses
Mar 24 • 108 min
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus.
539: Multitudes contain me
Mar 17 • 101 min
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant.
538: An Iowa caucus of viruses
Mar 9 • 61 min
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis.
537: Boundary issues
Mar 3 • 103 min
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses.
536: A flock of seagulls, a herd of seals
Feb 24 • 88 min
Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals.
535: Miles to go before I leak
Feb 17 • 96 min
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.
534: Portal to the METTL
Feb 10 • 94 min
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA.
533: Recurring threads
Feb 3 • 111 min
The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China.
532: Morbillivirus had a little lamb
Jan 27 • 98 min
The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus.
531: Circ du RNA
Jan 20 • 107 min
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses.
530: Quiet please!
Jan 13 • 102 min
Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.
529: Rueckert Road
Jan 8 • 75 min
At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager.
528: Our annual recapsidation
Jan 6 • 127 min
In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.
527: City mouse, country mouse
Dec 30, 2018 • 86 min
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.
526: In the beginning there was pol
Dec 23, 2018 • 104 min
The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.
Special: Vaccines Did Not Cause Rachel’s Autism
Dec 19, 2018 • 19 min
Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel’s Autism.
525: The A Bee Cs of bee viruses
Dec 16, 2018 • 98 min
Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses.
524: Slicing and dicing with Raul
Dec 12, 2018 • 76 min
Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.
523: Virology in Zürich
Dec 9, 2018 • 77 min
At the University of Zürich, Vincent speaks with virologists Cornel Fraeful, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.
522: Readers of the lost ORF
Dec 2, 2018 • 107 min
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.
521: Spitting in the Allee
Nov 25, 2018 • 114 min
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.
520: This old mouse
Nov 18, 2018 • 115 min
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.
519: Fishing for viruses in senile
Nov 11, 2018 • 95 min
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.
518: Hershey’s viruses
Nov 4, 2018 • 86 min
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.
517: Just in time for Halloween
Oct 28, 2018 • 79 min
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.
516: HUSH little virus, don’t you transcribe
Oct 21, 2018 • 120 min
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.
515: When virus is in retrograde
Oct 14, 2018 • 98 min
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia virus due to inhalation of ground up rabbit skin, and a how a human papillomavirus capsid…
514: Staying below the ADAR
Oct 7, 2018 • 108 min
The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.
513: Double-stranded in Belgium
Sep 30, 2018 • 62 min
From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.
512: Flexuous SUMO wrestlers
Sep 23, 2018 • 102 min
Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.
511: Accessory found guilty in DC
Sep 16, 2018 • 108 min
Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.
510: Retroviruses at Cold Spring Harbor
Sep 9, 2018 • 64 min
Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.
509: 41,103 bases under the sea
Sep 2, 2018 • 106 min
The TWiV team considers whether those who can do, can’t teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.
508: Bioweapon
Aug 26, 2018 • 127 min
Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.
507: The fusion of form and function
Aug 19, 2018 • 118 min
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.
Special: David Tuller is PACEman
Aug 17, 2018 • 68 min
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.
506: A Cafeteria full of jelly rolls
Aug 12, 2018 • 97 min
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.
505: Rosebola
Aug 5, 2018 • 122 min
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer’s disease.
504: Flying foxes and barking pigs
Jul 29, 2018 • 110 min
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years.
503: The greening of TWiV
Jul 22, 2018 • 61 min
Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants.
502: Texas road phage
Jul 13, 2018 • 91 min
The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria.
501: Outbreak
Jul 8, 2018 • 89 min
Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.
500: Keep virology weird
Jun 30, 2018 • 120 min
The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse.
499: Good virologists go to Halifax
Jun 24, 2018 • 58 min
Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research.
498: Salivating at ASM Microbe
Jun 17, 2018 • 68 min
Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research.
497: Europic 2018
Jun 10, 2018 • 59 min
At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research.
496: Vaccines work, whether or not you believe in them
Jun 3, 2018 • 75 min
Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction.
495: Influenza virus keeps its ion channel 20
May 27, 2018 • 111 min
The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry.
494: Ebola Makona is the opposite of hakuna matata
May 20, 2018 • 72 min
Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals.
493: Condit is on drugs and norovirus is lit
May 13, 2018 • 99 min
The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection.
492: CRISPR diagnostics
May 6, 2018 • 109 min
The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system.
491: The Ileum and the Odyssey
Apr 29, 2018 • 97 min
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells.
490: Shave ice and giant viruses
Apr 22, 2018 • 96 min
From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation.
489: CD4 Hunter
Apr 15, 2018 • 66 min
Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game ‘CD4 Hunter’.
488: Who nose if it will work in humans
Apr 8, 2018 • 102 min
The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain.
487: Milwaukee viral
Apr 1, 2018 • 63 min
At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers.
486: Sean Whelan on being haploid
Mar 25, 2018 • 63 min
Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.
485: Fishing with defective flies
Mar 18, 2018 • 85 min
The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.
484: Float like a mimivirus STING like a bat
Mar 11, 2018 • 86 min
The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.
483: Every infection is unhappy in its own way
Mar 4, 2018 • 101 min
Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.
482: Don’t EVEome without antibody expressed
Feb 25, 2018 • 97 min
The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome.
481: And biles to go before I delete
Feb 18, 2018 • 102 min
The TWiVodrome the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza.
480: The PFU in your achoo
Feb 11, 2018 • 113 min
Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases.
479: Trypsin the flight fantastic
Feb 4, 2018 • 110 min
The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and fungus in the mosquito gut that aids dengue virus replication.
478: A pox on your horse
Jan 28, 2018 • 101 min
The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments.
477: Raiders of the lost Arc
Jan 20, 2018 • 103 min
The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse.
476: In ACOD1 we trust
Jan 14, 2018 • 104 min
Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.
475: Everything is viral
Jan 7, 2018 • 110 min
In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.
474: Call me fish meal
Dec 31, 2017 • 103 min
The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth’s waters.
473: Assessing a risk and infecting you twice
Dec 24, 2017 • 109 min
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.
Special: Ray Ortega in the podcaster’s studio
Dec 20, 2017 • 60 min
Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast.
472: The riddle of the skinks
Dec 17, 2017 • 114 min
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
471: Songs of innocence and experience
Dec 10, 2017 • 108 min
The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.
470: Just a passing phage
Dec 3, 2017 • 116 min
The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues.
469: Mycovirus stuffed potatoes
Nov 26, 2017 • 108 min
The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science.
468: Zika by the slice
Nov 19, 2017 • 106 min
Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.
467: Jon and Ted’s Excellent Adventure
Nov 12, 2017 • 99 min
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.
466: The Capsid Club
Nov 5, 2017 • 65 min
From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.
465: Theodora the explorer
Oct 29, 2017 • 110 min
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.
464: Boston baked viruses
Oct 22, 2017 • 87 min
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.
463: We haven’t meth but these names ring Nobel
Oct 15, 2017 • 104 min
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.
Special: Tear it up with David Tuller
Oct 14, 2017 • 67 min
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.
462: Splicing RNA with Phillip A. Sharp
Oct 6, 2017 • 38 min
Nobel Laureate Phillip A. Sharp on his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.
461: Gotta trace them all!
Sep 30, 2017 • 127 min
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.
460: Penn, a great sandbox for science
Sep 24, 2017 • 92 min
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.
459: Polio turns over a new leaf
Sep 17, 2017 • 104 min
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.
458: Saliva of the fittest
Sep 9, 2017 • 118 min
The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.
457: The Red Queen meets the White Rabbit
Sep 3, 2017 • 123 min
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.
456: Be careful of canons
Aug 26, 2017 • 124 min
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.
455: Pork and genes
Aug 20, 2017 • 105 min
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.
454: FGCU, Zika
Aug 13, 2017 • 107 min
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.
453: Neurovirology with Diane Griffin
Aug 6, 2017 • 63 min
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.
452: Kiss that frog
Jul 29, 2017 • 112 min
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
451: Expectorate the unexpected
Jul 23, 2017 • 104 min
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
450: Ben tenOever and RNA out
Jul 16, 2017 • 95 min
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
449: The sound of non-silencing
Jul 9, 2017 • 101 min
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.