Revisiting the Gene
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The complete sequencing of the human genome is one of the most powerful examples of technology and science in action: We’ve gone from needing $3 billion and over 13 years to read a single human genome to today, to where we can do that same amount of work for about $1,000 in roughly 2 days — and the price will only continue to drop. But beyond pricing, what does understanding the gene — and moving from the sequencing layer to the applications layer — mean to us; what new questions arise now that we can sequence DNA quickly, reliably, and cheaply? This conversation — with co-founder and CEO of Jungla Carlos Araya and co-founder and CEO of Freenome Gabe Otte, moderated by a16z General Partner Jorge Conde (based on a discussion that took place at a16z’s annual Summit in November 2017) — takes a step back and considers all these questions. Every time a human genome sequence is completed, there are on the order of 3,000,000 new variants identified. So how do we think about interpreting all that data?…