This Week in Evolution

This Week in Evolution

microbe.tv/twievo
A podcast on the biology of what makes us tick


44: The enemy of my enemy is my phage
Jun 27 • 64 min
At ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria.
43: Social evolution with a side of shrimp
May 25 • 80 min
Dustin Rubinstein joins Nels and Vincent to discuss coevolution of genome architecture and social behavior, and studying social transitions in sponge-dwelling snapping shrimp.
42: Who’s who in your genome
Apr 24 • 78 min
Nels and Vincent review the contribution of multiple Denisovan lineages to the modern Papuan genome.
41: Where do baby genes come from?
Mar 20 • 84 min
Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model.
40: Eau de bee
Feb 14 • 71 min
Nels and Vincent move back to reproductive isolation - this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species.
39: In a Legionella of their own
Jan 26 • 77 min
Nels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens.
38: Evolving to evolve
Dec 24, 2018 • 80 min
Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics.
37: A tangled tree on the Quammens
Nov 17, 2018 • 91 min
David Quammen joins Nels and Vincent to talk about his new book, A Tangled Tree, including evolutionary trees, Carl Woese, Lynn Margulis, horizontal gene transfer, and much more.
36: All’s not quiet on the telomeric front
Oct 24, 2018 • 75 min
Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophilahave evolved in conflict with the genome.
35: Strawberry sex chromosomes forever
Sep 21, 2018 • 96 min
Nels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex.
34: You don’t know what you’ve got ‘til it’s PON
Aug 16, 2018 • 82 min
Nels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides.
33: Fly by virus
Jul 24, 2018 • 80 min
Nels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies.
32: Never not neutral
Jun 19, 2018 • 79 min
Matt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data.
31: Virus archaeology, or when the human genome is the junk
May 19, 2018 • 81 min
Nels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains.
30: Driving Miss Maize-y
Apr 21, 2018 • 75 min
Nels and Vincent reveal how a motor protein in corn causes preferential transmission of chromosomes to egg cells, leading to non-Mendelian inheritance.
29: Evolution on the wing
Mar 21, 2018 • 102 min
Nels and Vincent discuss the evolution of blood feeding to nonbiting in a mosquito, and evolution of bacterial virulence in the house finch caused by incomplete host immunity.
28: Genetics of skin pigmentation in Africa
Feb 27, 2018 • 79 min
Sarah Tishkoff joins Nels and Vincent to explain work from her laboratory on the genetic basis of skin pigmentation in Africans.
27: Coldevo
Jan 13, 2018 • 78 min
Taking a cue from the recent frigid weather, Nels and Vincent explore how modifications of a neuronal cold-sensing channel regulate diminished cold sensitivity in hibernating mammals.
26: My Scientist Vinny
Dec 7, 2017 • 73 min
Vinny Lynch joins Nels and Vincent to discuss how a zombie gene in elephants protects these large, long lived animals from cancer.
25: Pigeons show the way
Nov 22, 2017 • 98 min
Nels and Vincent discuss a genomic analysis of the passenger pigeon, which shows that species with large and stable populations may be at risk of extinction after a sudden environmental change.
24: Good viruses visiting bad neighborhoods
Oct 26, 2017 • 93 min
Marco Vignuzzi joins Nels and Vincent to discuss recent work from his laboratory on redirecting RNA virus evolution in sequence space.
23: The Alus are going to be alright
Sep 20, 2017 • 74 min
Nels and Vincent reveal how the protein DHX9 suppresses RNA processing defects caused by invasion of the Alu retroelement into the human genome.
22: E pluribus cerevisiae
Aug 30, 2017 • 81 min
Maitreya Dunham joins Nels and Vincent to explain how her laboratory uses experimental evolution to study yeast flocculation, the community-building cell aggregation trait.
21: A virus with a green thumb
Jul 12, 2017 • 105 min
Rich Condit joins Nels and Vincent to explain how a vaccinia virus protein customizes ribosomes to favor the translation of viral mRNAs with a stretch of A residues in the 5’-untranslated region. Hosts: Nels Elde and Vincent Racaniello…
20: In the company of cnidarians
Jun 19, 2017 • 102 min
Nels and Vincent explore the role of TSR proteins during colonization of cnidarians by dinoflagellates. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO TSR domain proteins in cnidarian-dinoflagellate…
19: The beauty of the story
May 24, 2017 • 84 min
Jonathan Weiner, author of the Pulitzer Prize-winning Beak of the Finch, joins Nels and Vincent to talk about his career and his writing. Hosts: Nels Elde and Vincent Racaniello Guest: Jonathan Weiner Become a…
18: Raiders of the lost orco
Apr 10, 2017 • 92 min
Hosts: Nels Elde and Vincent Racaniello Guests: Ni-Chen ‘Sylvia’ Chang, Waring ‘Buck’ Trible, and Sean K. McKenzie Buck and Sean join Vincent in New York, while Sylvia is with Nels in Salt Lake City to discuss the first mutant ant ever…
17: The curious cases of clam cancers
Mar 13, 2017 • 76 min
Hosts: Nels Elde and Vincent Racaniello Guest: Stephen Goff Nels joins Vincent in New York City to speak with Stephen Goff about transmissible clam cancers and the silencing of integrated retroviral genomes. Become a…
16: Breaking in the making of genes
Feb 25, 2017 • 77 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent reveal how introns - the parts of pre-mRNAs that are removed by splicing - were generated by DNA transposons in two different picoeukaryotes. …
15: From cockroaches to grizzly bears
Jan 22, 2017 • 105 min
Hosts: Nels Elde and Vincent Racaniello Guest: Hopi Hoekstra Nels and Vincent speak with Hopi Hoekstra about her career and the work of her laboratory on developmental mechanisms of stripe patterns in rodents. Become a…
14: TWi-light on the Wasatch Front
Dec 21, 2016 • 109 min
Hosts: Nels Elde and Vincent Racaniello Guests: Jessica Brown, Michael Kay, Wayne Potts, June Round, and Janis Weis From the Microbial Pathogenesis Retreat of the University of Utah School of Medicine,…
13: This week in ants
Nov 15, 2016 • 92 min
Hosts: Nels Elde and Vincent Racaniello Guest: Corrie Moreau Corrie joins Nels and Vincent to talk about her comparative analysis of the genomes of mutualist ants that nest in plants, and non-symbiotic species. …
12: Take a left at the goats
Oct 19, 2016 • 115 min
Hosts: Nels Elde and Vincent Racaniello Guest: Josh Drew Josh joins Nels and Vincent to talk about his research on the evolution and conservation of aquatic tropical biodiversity, and the historical…
11: Microbial accomplices in multicellularity
Sep 27, 2016 • 105 min
Hosts: Nels Elde and Vincent Racaniello Guest: Nicole King Nicole joins Nels and Vincent to discuss the finding of her laboratory that multicellular development of choanoflagellates, the closest living relatives…
10: Spicing up peppered moths with a selfish gene
Aug 13, 2016 • 94 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent review experiments showing that the replacement of a pale moth with a black one during the industrial revolution was caused by a transposable element. Links for this…
9: How to crash your gene drive
Jul 5, 2016 • 98 min
Hosts: Nels Elde and Vincent Racaniello Guest: Jim Bull Nels and Vincent speak with Jim Bull about the results of genetic models which suggest that the evolution of inbreeding in response to lethal gene drive might make…
8: Everyone’s a little bit Neanderthal
Jun 8, 2016 • 97 min
Hosts: Nels Elde and Vincent Racaniello Nels visits Vincent in the MicrobeTV studio in New York and talks about how key genes of the Homo sapiens innate immune response were acquired from Neanderthals. Links…
7: Pigeon fashion week, feathery boots edition
Apr 23, 2016 • 83 min
Hosts: Nels Elde and Vincent Racaniello Guest: Mike Shapiro Mike joins Nels and Vincent to talk about his work on what controls whether pigeons have scaly or feathered feet, and reveals that the hindlimbs of…
6: Butterflies are free to shuffle
Mar 18, 2016 • 102 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent continue with an emerging sub-theme of TWiEVO - organisms with wings - as they reveal how enhancer shuffling produces diverse butterfly wing patterns. Links for…
5: Looking at straw colored fruit bats through a straw
Feb 20, 2016 • 98 min
Hosts: Nels Elde and Vincent Racaniello Guests: Kartik Chandran and Sara Sawyer Sara and Kartik join Nels and Vincent to talk about the filovirus receptor NPC1 regulates Ebolavirus susceptibility in…
4: Taking the mystery out of the mystery of mysteries
Jan 23, 2016 • 95 min
Hosts: Nels Elde and Vincent Racaniello Guest: Nitin Phadnis Nitin joins Nels and Vincent to explain how he identified a gene that is responsible for male inviability in hybrids from a cross between two species of fruit…
3: Recombination is for the birds
Jan 9, 2016 • 82 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent discuss the evolution of recombination in the genomes of birds and yeast. Links for this episode Stable recombination hotspots in birds…
2: Faster than a speeding virus
Dec 26, 2015 • 73 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent talk about how a cellular enzyme contributes to the very high mutation rate of human immunodeficiency virus type 1. Links for this episode Cell defense…
1: When (scientific) worlds collide
Dec 12, 2015 • 73 min
Hosts: Nels Elde and Vincent Racaniello Nels and Vincent launch a new podcast on evolution, and start by discussing how the field has changed through recent mergers of evolutionary and experimental biology in the post-genome era. Links for…